Impact of Family History on Life Expectancy

A hereditary disease is caused by genetic factors transmitted from parent to offspring. Family history is, therefore, an important consideration in life expectancy evaluation for insurance risk evaluation and policy valuation.

In addition to genetic transmission family history can expose lifestyle diseases as well.  Sometimes diseases like diabetes or heart conditions link to family behavior.

Breast cancer is probably the most common genetic disorder that passes from mother to daughter to granddaughter. Most inherited cases of breast cancer are associated with two abnormal genes: BRCA1 (BReast CAncer gene 1) or BRCA2 (BReast CAncer gene 2). Women who inherit a mutation, or abnormal change, in either of these genes — from their mothers or their father’s family — have a much higher-than-average lifetime risk of developing breast cancer and ovarian cancer. Women with this gene are at 72% risk of developing it. It is also estimated that about 44% of women who inherit a harmful BRCA1 develop ovarian cancer.

Early signs and symptoms of sickle cell disease include swelling of the hands and feet; symptoms of anemia, and jaundice. Over a lifetime, sickle cell disease can harm a patient’s spleen, brain, eyes, lungs, liver, heart, kidneys, penis, joints, bones, or skin. We look closely at these signs and symptoms when there is a family history of sickle cell anemia. In the United States, most people who have sickle cell disease are of African ancestry, but the condition is also common in people with a Hispanic background.

Canavan disease is a rare inherited disorder that damages the ability of nerve cells in the brain to send and receive messages. Neonatal Canavan disease is the most common and most severe form of the condition. Affected infants show signs by age 3 to 5 months, problems with development become noticeable. These infants usually do not develop motor skills such as turning over, controlling head movement, and sitting without support. Other common features of this condition include weak muscle tone (hypotonia), an unusually large head size, and irritability. Feeding and swallowing difficulties, seizures, and sleep disturbances may also develop. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. Telegenisys creates a list of these symptoms for the reviewer to study individual symptoms and the effects of these on the patient.

Experts at Telegenisys watch out for family history and any such related symptoms are highlighted for the reviewer in insurance and life expectancy evaluations.

Deep probes of medical records for genetic evaluations:

To help underwriters and researchers, Telegenisys builds genetic datasets which are applied to medical records.  Each genetic factor is described and its incidence in medical records is identified chronologically by Telegenisys medical software. These deep data probes often expose symptomatology presented on timelines which clarify the duration and  intensity of the disease.

These important factors are used by underwriters in their evaluation of insurance applicants and life expectancy valuations.  Researchers are using these to evaluate disease history for natural history studies and clinical studies.


References:

https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet

https://www.nhlbi.nih.gov/health-topics/sickle-cell-disease

https://ghr.nlm.nih.gov/condition/canavan-disease#inheritance

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